Avoid showering, bathing, swimming, and participating in activities that result in sweating.
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TV remote control, computer keyboard or mouse).ĭo not get the infusor wet. Prior to preparing or applying the on-body infusor, read and become familiar with the manufacturer's 'Instructions for Use'.ĭuring the 5-hour subcutaneous infusion, limit activity, especially bending movements, and avoid riding in a car or flying in an airplane.ĭo not use the on-body infusor within 12 inches of mobile phones, tablets, computers or wireless accessories (e.g. Subcutaneous furosemide infusion via On-Body Infusor (Furoscix): The risk of ototoxicity increases with more rapid parenteral administration. Infuse at a rate not to exceed 4 mg/minute in adults or 0.5 mg/kg/minute in children. NOTE: Furosemide is not FDA-approved for continuous IV administration. Infuse at a rate not to exceed 0.5 mg/kg/minute or for high dose therapy, do not exceed 4 mg/minute. In pediatric patients, injection no faster than 0.5 mg/kg/minute more rapid administration increased the risk of ototoxicity.įor patients receiving extracorporeal membrane oxygenation (ECMO), administer IV furosemide outside the circuit the drug is substantially adsorbed by circuit components. Inject each 20 to 40 mg of furosemide slowly IV over 1 to 2 minutes. Some authors caution against the routine use of furosemide following PRBC transfusions due to a lack of efficacy data and the potential for electrolyte imbalance.ĭilute in 0.9% Sodium Chloride Injection, Lactated Ringer's Injection, or 5% Dextrose Injection adjust pH to more than 5.5 when necessary.ĪSHP Recommended Standard Concentrations for Adult Continuous Infusions: 2 mg/mL or 10 mg/mL.ĪSHP Recommended Standard Concentrations for Pediatric Continuous Infusions: 2 mg/mL or 10 mg/mL. The authors noted no difference in the clinical respiratory status between the 2 groups.
There was no observed improvement in these values in the untreated group. The infants that received furosemide demonstrated an improvement in lung compliance, tidal volume, and minute ventilation compared to baseline.
The PRBCs were administered at a rate of 5 mL/kg/hour, and furosemide was given in 16 of the 24 cases. The infants were 6.1 +/- 2.9 weeks of age (32.5 +/- 3.4 weeks mean gestational age at birth) and all had bronchopulmonary dysplasia.
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One prospective, unblinded trial evaluated furosemide 1 mg/kg IV after transfusions of 10 mL/kg of packed red blood cells (PRBC) in 24 cases 3 of the 21 infants were studied twice. Although use in clinical practice is not uncommon, limited published data are available evaluating furosemide prior to or after the administration of blood products.
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